TOPGEAR: A Randomized, Phase III Trial of Perioperative ECF Chemotherapy with or Without Preoperative Chemoradiation for Resectable Gastric Cancer: Interim Results from an International, Intergroup Trial of the AGITG, TROG, EORTC and CCTG

T Leong; BM Smithers; K Haustermans; M Michael; V Gebski; D Miller; J Zalcberg; A Boussioutas; M Findlay; RL O’Connell; J Verghis; D Willis; T Kron; M Crain; WK Murray; F Lordick; C Swallow; G Darling; J Simes; R Wong

Journal article

TOPGEAR: A Randomized, Phase III Trial of Perioperative ECF Chemotherapy with or Without Preoperative Chemoradiation for Resectable Gastric Cancer: Interim Results from an International, Intergroup Trial of the AGITG, TROG, EORTC and CCTG

T Leong, BM Smithers, K Haustermans, M Michael, V Gebski, D Miller, J Zalcberg, A Boussioutas, M Findlay, RL O’Connell, J Verghis, D Willis, T Kron, M Crain, WK Murray, F Lordick, C Swallow, G Darling, J Simes, R Wong

Annals of Surgical Oncology | Published : 2017

DOI: 10.1245/s10434-017-5830-6

Abstract

Background: Postoperative chemoradiation and perioperative chemotherapy using epirubicin/cisplatin/5-fluorouracil (ECF) represent two standards of care for resectable gastric cancer. In the TOPGEAR (Trial Of Preoperative therapy for Gastric and Esophagogastric junction AdenocaRcinoma) trial, we hypothesized that adding preoperative chemoradiation to perioperative ECF will improve survival; however, the safety and feasibility of preoperative chemoradiation have yet to be determined. Methods: TOPGEAR is an international phase III trial in which patients with adenocarcinoma of the stomach were randomized to perioperative ECF alone or with preoperative chemoradiation. The ECF-alone group receive..

View full abstract

University of Melbourne Researchers

Trevor Leong Author

Michael Michael Author

Alex Boussioutas Author

Tomas Kron Author

Related Projects (1)

TOPGEAR: TRIAL OF PREOPERATIVE THERAPY FOR GASTRIC AND ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMA. A RANDOMISED PHASE TIL TRIAL OF PREOPERATIVE CHEMORADIOTHERAPY VERSUS PREOPERATIVE CHEMOTHERAPY FOR RESECTABLE GASTRIC CANCER

While surgery to remove gastric (stomach) cancer has been traditionally accepted as the only way to potentially cure the disease, there have..

Grants

Awarded by Health Research Council of New Zealand

Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council (1046425), Canadian Institutes of Health Research (CIHR) Grant No. 119445, the Canadian Cancer Society Research Institute (CCSRI) Grant No. 021039, the Health Research Council of New Zealand (HRC) International Investment Opportunities Fund (contract number 09/624), the EORTC Cancer Research Fund, and the Cancer Australia Priority-Driven Collaborative Research Scheme (Project ID 570996). Rhana Pike, from the National Health and Medical Research Council (NHMRC) Clinical Trials Centre, assisted with the manuscript.